Tumor Cell Models Engineered Cell Models

HELP

User Manual

E-Mail

Hi, Guest G

Tumor Cell Models

A premier tumor model database to empower cancer research

Home Model Gene Drug Help

Modify Query

Name: | Alias:

Cellosaurus RRID: | COSMIC ID: | Cell Model Passport: | DepMap ID: | CCLE Name:

Source: | Catalogue:

Overview

Basic Information

Disease: | Disease subtype: | Details:

Lineage: | Lineage Subtype: | Lineage Sub-subtype: | Lineage molecular subytype:

Gender: | Age at sampling:

Sample collection site: | Tissue status:

Culture type: | Culture medium:

Cell Culture Images

Model Genomics

HLA:

MSI:

ploidy_snp6:

ploidy_wes:

ploidy_wgs:

Viral infection :

Data availability:

STR Markers

Genomics

1.Visualize genomics information including mRNA expression, mutations, copy number alterations, gene fusions, etc.

2.Driver Genes provides an overview of cancer driver gene status in the query model.

3.In All Genes, you can search for genes of interest.

Driver Genes
All Genes

Note: Displays genes acting as cancer drivers in this model.

Mutations (Driver Gene Method of Action)
Gain of function
Loss of function
Ambiguous Function
Fusion

Copy Number Alterations (CN Call)
Amplification of a driver gene (CN>=4.0)
Loss/Deletion of a driver gene (CN<=0.5)

Gene Fusion
Gene fusion

Spiral: Archimedean Rectangular

Legend: For mutations, font size is proportional to mutation frequency ranging from 0.05 to 1. For CNA, font size is inversely proportional to CN if CN <=0.5 and is proportional to CN if CN>=4.0. For gene fusions, font size is always 1. When a gene has both mutation and CNA, the mutation color coding and font size are used.

Legend

Mutation types are as follows:

Missense_Mutation(putative driver)
Frame_Shift_Del(unknown significance)
Frame_Shift_Ins(putative driver): Nonsense, Nonstop, Frameshift deletion, Frameshift insertion, Splice site
In_Frame_Del(unknown significance): Nonsense, Nonstop, Frameshift deletion, Frameshift insertion, Splice site
In_Frame_Ins(putative driver): Inframe deletion, Inframe insertion
Nonsense_Mutation(putative driver)
Nonstop_Mutation(putative driver)
Splice_Site(putative driver)
Start_Codon_SNP(putative driver)

Pharmacology

Visualization of pharmacological data collected from various reference databases. You can select one source for data visualization. Drug efficacy is represented by IC50 and AUC for in vitro CTG assays.

Select source:

Sort by:

IC50 Ascending AUC Ascending

Show all Clear all

Analytics

1.Overview of models based on gene expression landscape, visualized through UMAP analysis of the entire transcriptome.

2.Genetic Analysis shows: (a) the query model's genome ancestry; (b) its genetic similarity to other models, with highly identical ones marked in red; (c) the variant allele frequency (VAF) by cancer type.

3.Efficacy Similarity identifies models with drug response patterns highly similar to the query model.

4.Pathway Activation highlights pathways that are either highly activated or suppressed in the query model.

Overview
Genetic Analysis
Efficacy Similarity
Pathway Activation

Genome Ancestry
Genetic Similarity to Other Cell Lines
Variant Allele Frequency (VAF)

VAF

Alphabetical

Select source:

Pathway status:

Activated Suppressed

Pathway database:

Ranking metascore (descending) in all cell lines:

top or bottom 1% top or bottom 5%

Show more Show less

Switching operation：

Pathway activity score

Alphabetical

CONTACT US

Email: info@cobioer.com

HELP

Overview

Genomics 1.Visualize genomics information including mRNA expression, mutations, copy number alterations, gene fusions, etc. 2.Driver Genes provides an overview of cancer driver gene status in the query model. 3.In All Genes, you can search for genes of interest.

Pharmacology Visualization of pharmacological data collected from various reference databases. You can select one source for data visualization. Drug efficacy is represented by IC50 and AUC for in vitro CTG assays.

CONTACT US

AI Chat

Genomics

1.Visualize genomics information including mRNA expression, mutations, copy number alterations, gene fusions, etc.

2.Driver Genes provides an overview of cancer driver gene status in the query model.

3.In All Genes, you can search for genes of interest.

Pharmacology

Visualization of pharmacological data collected from various reference databases. You can select one source for data visualization. Drug efficacy is represented by IC50 and AUC for in vitro CTG assays.